Job: Principal Scientist, Exploratory Toxicology Job

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Jobing Description

Job Title:
Principal Scientist, Exploratory Toxicology

Job ID:
12777

Location:

San Diego, CA
Offsite Territory:
Full/Part Time: Full-Time

Regular/Temporary:
Regular

Category:

Research

Department:

NCD - Exploratory Toxicology - 3256


Celgene Corporation is committed to delivering innovative therapies designed to improve the lives of patients worldwide. We are a global biopharmaceutical company with operations in more than 70 countries that is helping to turn incurable cancers into chronic, manageable conditions. We are seeking talented professionals as we continue to grow and advance our efforts in oncology, hematology and immune and inflammatory disease. If you would like to join a company where you can make a difference, please consider the Celgene family.

Degree:

An advanced graduate degree in a relevant field, generally a Ph.D. in toxicology, with extensive training and industry experience in Toxicology and an excellent understanding of early stage drug discovery and development process. American Board of Toxicology certification desired. A Doctorate of Veterinary Medicine or equivalent degree considered an advantage.

Years of Experience:

Minimum 8 years experience. Experience in pharmaceutical or related industry, preferred.

Industry Knowledge:

Advanced knowledge of general toxicology principles and experience conducting exploratory in vivo studies including cardiovascular safety pharmacology. It will be critical that this individual have an investigative aptitude and eager to embrace safety risk mitigation challenges. Familiarity with in vivo toxicology study design, conduction, and reporting considered critical. Experience as a safety representative on either Research or Development project teams is essential.

Overview

The Principal Scientist in Exploratory Toxicology will direct the in vivo toxicology efforts for Celgene Research and serve as an integral member of the toxicology team that supports the early stage discovery and development of pharmaceuticals, including the identification, mechanistic investigation, and management of safety risk from initial Target Identification to Development Candidate nomination stages. In general, scientist will provide appropriate scientific perspective to identify safety issues early in the drug development process of a potential drug candidate. This scientist will manage and supervise scientific, administrative, and technical activities related to In Vivo Toxicology with emphasis on Discovery Project Team support, including identification, characterization, and management of safety issues. Additionally, this individual will provide in vivo and exploratory toxicology support for mechanistic studies of later stage development candidate compounds.

The Senior Scientist is also responsible for assisting the Senior Director of Exploratory Toxicology in establishing and achieving long-term strategic goals and tactical objectives of the Exploratory Toxicology group.

Responsibilities will include the following:

1. Establish and manage an in vivo laboratory focused primarily on supporting the Celgene Research Portfolio and secondarily on identification of mechanistic basis of toxicity, including the following capacities.
1. Overall design, conduct, and reporting in vivo exploratory toxicology studies
2. Manage technical staff responsible for conducting short term in vivo toxicology studies, clinical chemistry and hematology analysis
3. Serve as study manager/monitor on toxicology and screening safety pharmacology studies at appropriate contract research organizations
4. Support the preparation of study reports and documents needed for regulatory submissions, relating to exploratory toxicology efforts

2. Serve as Research Project Team toxicology representative and manage safety risk identification program for that project(s).
3. Provide guidance and mentoring for study directors of investigative and early stage compound studies, including safety pharmacology and dose range-finding studies.
4. Oversee quality, quantity, and performance of In Vivo Toxicology laboratory, including managing technical staff.
5. Facilitate collaboration with academic centers and toxicology consultants as necessary to complete investigative studies.
6. Maintain toxicology expertise through organizational associations, literature review, continuing education, and publications.
7. Establish and maintain working relationship with key opinion leaders in the toxicology community, academicians, and key Celgene staff
8. Support Development Toxicology by
1. Managing In Vivo Toxicology laboratory focused on identification of safety risk in animals
2. Interacting with scientific staff
3. Publishing findings
4. Addressing potential development issues and conducting risk mitigation activities

9. Address scientific issues using knowledge of toxicology


Skills/Knowledge Required:

See Prerequisites above

Communication Skills

Strong verbal and written skills; ability to provide focus and clarity; able to handle confidential information and material appropriately. Ability to anticipate resource needs and helps establish priorities. Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view.

Strategic Decision Making

Strategic thinker who can balance near term objectives with long term goals and outcomes, evaluate risk and develop effective solutions through an integrated multi-disciplined decision-making approach.

Team player, mentoring ability

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Celgene support of a potential employee's temporary visa application be construed to guarantee success of that application or amend or otherwise invalidate the "at-will" employment relationship between the employee and Celgene.