Postdoctoral Fellow in Immunotherapy (Calibr)

Job ID: N155. This position is with the California Institute for Biomedical Research (Calibr). To learn more about this opportunity and/ or to apply for consideration, please go to https://www.scripps.edu/science-and-medicine/calibr/careers/

The California Institute for Biomedical Research (Calibr) is a not-for-profit research institute located in La Jolla, California. Calibr is focused on innovative early-stage translational research in the areas of regenerative medicine, cancer biology, cardiovascular and metabolic disease, immunology and infectious disease.

Position Overview:
This postdoctoral fellow will work as part of a small team of interdisciplinary scientists to translate novel cell and protein therapies for the treatment of cancer into human clinical trials. Specifically, the project will focus on the development of a next-generation CAR-T cell strategies for the treatment of cancer. This opportunity is ideal for postdocs who are interested in learning the drug discovery process and who want to make an impact by being part of a small dynamic team of scientists working at the cutting edge of cellular immunotherapy.

Essential Duties and Responsibilities:
* Research, design, and execution of cutting-edge programs in cellular and protein sciences.
* Cell biology including working with primary human immune cells and culturing multiple cell lines including, but not limited to, common tumor cell lines used in immuno-oncology research.
* Execution of experiments involving immune cell profiling, cell processing from xenograft models, cytotoxicity, proliferation, activation, cell viability, and survival assays with a strong focus on flow cytometry.
* Generation of reagents for projects including preparation of lentivirus for the transduction of both established cell lines and primary immune cells.
* Molecular biology experiments including DNA and protein preparation from cells, immunoprecipitation, Western blots, etc. will be.
The California Institute for Biomedical Research (Calibr) is a not-for profit research institute located in La Jolla, California. Calibr is focused on innovative early stage translational research in the areas of regenerative medicine, cancer biology, cardiovascular and metabolic disease, immunology and infectious disease.
* Preparation of reports and presentation of results at regular team meetings.

"The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status."

This position is with the California Institute for Biomedical Research (Calibr). To learn more about this opportunity and/ or to apply for consideration, please go to https://www.scripps.edu/science-and-medicine/calibr/careers/

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions.

Details of established essential functions for this position will be addressed/discussed during the interview process
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* A strong background in cell culture is essential.
* Experience and knowledge of the immune system are a required. Experience in T cell biology, tumor immunology, as well as other immune components is preferred.
* Hands-on experience with in vitro assays commonly used in immuno-oncology, and experience preparing reagents for in vivo assays. In vivo experience preferred but not required.
* Experience with multi-color flow cytometry and flow data analysis is required.
* Experience with cell transfection and transduction systems is preferred.
* Experience with molecular biology techniques is preferred.
* Experience using Prism, FlowJo, and Office software is important.

Qualifications:
* Ph.D. in biology, chemical biology, biochemistry or related area. Recent Ph.D. graduate or prior postdoctoral experience are both appropriate.
* Impeccable attention to detail, and excellent ability to perform hands-on experiments, research, design, and organize project designs and maintain detailed documentation.
* Highly motivated, creative, and devoted to project goals.
* Able to collaborate proficiently and communicate effectively with colleagues and management teams.
* Able to contribute in a meaningful way to scientific discourse.

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.